INDUCTION OF PROSTATE APOPTOSIS BY DOXAZOSIN IN BENIGN PROSTATIC HYPERPLASIA
作者： NATASHA KYPRIANOU , JUAN P. LITVAK , ANDREW BORKOWSKI , RICHARD ALEXANDER , STEPHEN C. JACOBS
DOI: 10.1016/S0022-5347(01)63162-8
关键词: Desmin 、 Prostate 、 Medicine 、 Terminal deoxynucleotidyl transferase 、 Stromal cell 、 Adenoma 、 Doxazosin 、 Hyperplasia 、 Stroma 、 Pathology
摘要: AbstractPurpose: The molecular mechanisms underlying the therapeutic effect of alpha 1 blocker, doxazosin, on benign prostatic hyperplasia (BPH) are poorly understood. We evaluated doxazosin cell proliferation and apoptosis in glandular epithelium stroma patients with BPH.Materials Methods: examined proliferative apoptotic activities prostate specimens 22 men a mean 65 years old BPH before after treatment within normal range. Proliferative indexes were determined using Ki-67 nuclear antigen staining terminal transferase end labeling assay, respectively. smooth muscle content was identified by alpha-actin, desmin immunoreactivity correlated stromal tissue regression improvement symptoms.Results: In response to there no significant changes kinetics p...
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