Base Excision Repair in Physiology and Pathology of the Central Nervous System
作者： Matthias Bosshard , Enni Markkanen , Barbara van Loon
关键词: Biology 、 Genome instability 、 DNA damage 、 Pathology 、 DNA Repair Pathway 、 DNA repair 、 Genotoxic Stress 、 Oxidative stress 、 DNA 、 Base excision repair
摘要: Relatively low levels of antioxidant enzymes and high oxygen metabolism result in formation numerous oxidized DNA lesions the tissues central nervous system. Accumulation damage DNA, due to continuous genotoxic stress, has been linked both aging development various neurodegenerative disorders. Different repair pathways have evolved successfully act on damaged prevent genomic instability. The predominant essential pathway for removal small base is excision (BER). In this review we will discuss current knowledge involvement BER proteins maintenance genetic stability different brain regions how changes these contribute onset
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