The global distribution and evolution of deoxyribonucleoside kinases in bacteria

摘要: Deoxyribonucleoside kinases (dNKs) are important to DNA metabolism, especially in environments where nucleosides freely available be absorbed and used for the salvage pathway. Little has previously been known about complement of dNKs different bacterial genomes. However, it was believed that Gram-negative bacteria had a single dNK, while Gram-positive possessed several. An analysis 992 fully sequenced genomes, including both organisms, conducted investigate phylogenetic relationship all TK1-like non-TK1-like dNKs. It illustrated gene families evolved through number duplications horizontal transfers, leading presence multiple types bacteria. The findings this study provide backbone further studies into evolution interplay between de novo pathways synthesis with respect environmental availability deoxyribonucleosides metabolic processes generating provisions dNTPs.