Annexins as nucleotide-binding proteins: facts and speculations.

摘要: Annexins are ubiquitous multifunctional Ca2+ and phospholipid-binding proteins whose mechanism of function remains largely unknown. The accumulated in vitro experimental evidence indicates that ATP GTP functional ligands for nucleotide-sensitive annexin isoforms. Such nucleotide binding could modulate homeostasis, vesicular transport and/or signal transduction pathways link them to cellular energy metabolism. Alternatively, since annexins able interact with other nucleotide-utilizing proteins, such as various kinases, GTPases structural these influence the guanine exchange metabolism control activity G proteins. nucleotide-binding properties may affect development or maintenance some pathologies diseases which changes physiological concentrations purine nucleotides disruption homeostasis crucial targets.