Sensory sensitivity as a link between concussive traumatic brain injury and PTSD.
作者： Ann N. Hoffman , Jamie Lam , David A. Hovda , Christopher C. Giza , Michael S. Fanselow
DOI: 10.1038/S41598-019-50312-Y
关键词: Neuroscience 、 Sensory processing 、 Medial geniculate nucleus 、 Fear conditioning 、 Thalamus 、 Population 、 Traumatic brain injury 、 Amygdala 、 Traumatic stress 、 Medicine
摘要: Traumatic brain injury (TBI) is one of the most common injuries to military personnel, a population often exposed stressful stimuli and emotional trauma. Changes in sensory processing after TBI might contribute TBI-post traumatic stress disorder (PTSD) comorbidity. Combining an animal model with trauma, we reveal interaction between auditory sensitivity fear conditioning where 75 dB white noise alone evokes phonophobia-like phenotype when paired footshocks, robustly enhanced. reduced neuronal activity hippocampus but increased ipsilateral lateral amygdala (LA) noise. The effect LA was driven by neurons projecting from thalamus (medial geniculate nucleus). These data suggest that altered within subcortical sensory-emotional circuitry results neutral adopting aversive properties corresponding impact on facilitating trauma memories may TBI-PTSD
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