XPA: A key scaffold for human nucleotide excision repair

作者: Norie Sugitani , Robert M. Sivley , Kelly E. Perry , John A. Capra , Walter J. Chazin

DOI: 10.1016/J.DNAREP.2016.05.018

关键词: GeneticsBiologyDNA repairXeroderma pigmentosumNucleotide excision repairGenomeProliferating cell nuclear antigenNLSTranscription factor II HDNA

摘要: Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet mechanisms NER in humans remain poorly understood. This review summarizes our current understanding structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations one critical proteins, XPA.

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