Enhancement of bile acid pool size, synthesis and secretion by epomediol in the rat.

摘要: Epomediol is a terpenoid compound that has been reported to reverse 17a-ethinylestradiolinduced cholestasis and have choleretic effect related the biliary secretion of epomediol glucuronide. The aim this study was investigate contribution changes in bile acid metabolism epomediol-induced effects on formation. Twenty-four-hour collections were performed animals had received intraperitoneal for five days at 100 mg/kg daily. Epomediol-treated rats 24% larger pool 28% greater synthesis than controls when measured by “washout” technique. There no change fractional turnover rate cycling frequency pool. Both basal flow significantly increased (142% 174%, respectively). Linear regression analysis between revealed both acid-dependent fraction acid-independent (140 127, respectively), with capacity acids. Cholesterol 42%, but there significant differences phospholipid secretion. 7a-hydroxylase HMG-CoA reductase activities higher epomediol-treated (139% 197%, NADPHcytochrome c aniline hydroxylase also elevated (126% 164%, It concluded treatment expands through an enhanced synthesis. Choleresis induced drug partly increase