Design and Syntheses of New Antibiotics Inspired by Nature's Quest for Iron in an Oxidative Climate.
作者： Marvin J Miller , Rui Liu
DOI: 10.1021/ACS.ACCOUNTS.1C00004
关键词: Microbiology 、 Antibiotic resistance 、 Antibiotics 、 Bacteria 、 Monobactams 、 Bacterial cell structure 、 Efflux 、 Siderophore 、 Biology 、 Assimilation (biology)
摘要: Conspectus This Account describes fundamental chemistry that promoted the discovery of new antibiotics. Specifically, the NH acidity of simple hydroxamic acid derivatives facilitated …
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sci-hub.st 参考文章(87)
Yun-Ming Lin, Manuka Ghosh, Patricia A. Miller, Ute Möllmann, Marvin J. Miller, Synthetic sideromycins (skepticism and optimism): selective generation of either broad or narrow spectrum Gram-negative antibiotics Biometals. ,vol. 32, pp. 425- 451 ,(2019) , 10.1007/S10534-019-00192-6
Jingdan Hu, Marvin J. Miller, Total Synthesis of a Mycobactin S, a Siderophore and Growth Promoter of Mycobacterium Smegmatis, and Determination of its Growth Inhibitory Activity against Mycobacterium tuberculosis Journal of the American Chemical Society. ,vol. 119, pp. 3462- 3468 ,(1997) , 10.1021/JA963968X
David M. Floyd, Alan W. Fritz, Christopher M. Cimarusti, Monobactams. Stereospecific synthesis of (S)-3-amino-2-oxoazetidine-1-sulfonic acids Journal of Organic Chemistry. ,vol. 13, pp. 176- 178 ,(1982) , 10.1021/JO00340A048
Phillip G. Mattingly, James F. Kerwin, Marvin J. Miller, A facile synthesis of substituted N-hydroxy-2-azetidinones. A biogenetic type .beta.-lactam synthesis Journal of the American Chemical Society. ,vol. 101, pp. 3983- 3985 ,(1979) , 10.1021/JA00508A056
Jingdan Hu, Marvin J. Miller, A New Method for the Synthesis ofN.epsilon.-Acetyl-N.epsilon.-hydroxy-L-lysine, the Iron-Binding Constituent of Several Important Siderophores Journal of Organic Chemistry. ,vol. 59, pp. 4858- 4861 ,(1994) , 10.1021/JO00096A030
Marvin J. Miller, Francois Malouin, Microbial iron chelators as drug delivery agents: the rational design and synthesis of siderophore-drug conjugates Accounts of Chemical Research. ,vol. 26, pp. 241- 249 ,(1993) , 10.1021/AR00029A003
Manuka Ghosh, Patricia A. Miller, Marvin J. Miller, Antibiotic repurposing: bis-catechol- and mixed ligand (bis-catechol-mono-hydroxamate)-teicoplanin conjugates are active against multidrug resistant Acinetobacter baumannii. The Journal of Antibiotics. ,vol. 73, pp. 152- 157 ,(2020) , 10.1038/S41429-019-0268-7
Alita A. Miller, Adam B. Shapiro, Sarah M. McLeod, Nicole M. Carter, Samir H. Moussa, Ruben Tommasi, John P. Mueller, In Vitro Characterization of ETX1317, a Broad-Spectrum β-Lactamase Inhibitor That Restores and Enhances β-Lactam Activity against Multi-Drug-Resistant Enterobacteriales, Including Carbapenem-Resistant Strains ACS Infectious Diseases. ,vol. 6, pp. 1389- 1397 ,(2020) , 10.1021/ACSINFECDIS.0C00020
Danah Al Shaer, Othman Al Musaimi, Beatriz G. de la Torre, Fernando Albericio, Hydroxamate siderophores: Natural occurrence, chemical synthesis, iron binding affinity and use as Trojan horses against pathogens. European Journal of Medicinal Chemistry. ,vol. 208, pp. 112791- ,(2020) , 10.1016/J.EJMECH.2020.112791
Vineeta Rai, Nathaniel Fisher, Owen W. Duckworth, Oliver Baars, Extraction and Detection of Structurally Diverse Siderophores in Soil Frontiers in Microbiology. ,vol. 11, pp. 581508- ,(2020) , 10.3389/FMICB.2020.581508