Translational regulation during stage transitions in malaria parasites

摘要: The complicated life cycle of the malaria parasite involves a vertebrate host and mosquito vector, translational regulation plays prominent role in orchestrating developmental events two transition stages: gametocytes sporozoites. Translational is executed both global transcript-specific manners. Plasmodium uses conserved mechanism involving phosphorylation eIF2α to repress protein synthesis during latent period sporozoite development salivary glands. Transcript-specific achieved by network RNA-binding proteins (RBPs), among which Dhh1 RNA helicase DOZI Puf family RBPs are far best studied Plasmodium. While complex defines new P granule with protecting certain gametocyte mRNAs from degradation, appear expression These examples underscore significance development.