Memory accuracy predicts hippocampal mTOR pathway activation following retrieval of contextual fear memory.

摘要: Prior work suggests hippocampus-dependent memory undergoes a systems consolidation process such that recent memories are stored in the hippocampus, while older independent of hippocampus and instead dependent on cortical areas. One problem with interpreting these studies is for contextual stimuli weakens as time passes between training event testing often less detailed, making it difficult to determine if storage related age or accuracy memory. Activity mammalian target rapamycin (mTOR) signaling pathway known be important controlling protein translation necessary both after initial learning reconsolidation retrieval. We tested whether p70s6 kinase (p70s6K), key component mTOR pathway, activated following retrieval context fear dorsal (DH) anterior cingulate cortex (ACC) at 1, 10 36 days conditioning. also strengthening changed p70s6K phosphorylation structures training. show under standard conditions recently formed initially precise involves DH. Over loses detail, becomes DH, depends ACC. In subsequent experiment we preserved through pre-exposure context. remote still involved DH animals given pre-exposure. These data support notion detailed depend regardless their age.