Chemomimetic biocatalysis: exploiting the synthetic potential of cofactor-dependent enzymes to create new catalysts.

摘要: Despite the astonishing breadth of enzymes in nature, no are known for many valuable catalytic transformations discovered by chemists. Recent work enzyme design and evolution, however, gives us good reason to think that this will change. We describe a chemomimetic biocatalysis approach draws from small-molecule catalysis synthetic chemistry, enzymology, molecular evolution discover or create with non-natural reactivities. illustrate how cofactor-dependent can be exploited promote reactions first established related chemical catalysts. The cofactors biological, they non-biological further expand possibilities. ability amplify precisely control reactivity their together optimize directed promises yield exceptional catalysts challenging have biological counterparts.