Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung.

作者： Donatella Malanga , Marianna Scrima , Carmela De Marco , Fernanda Fabiani , Nicola De Rosa

关键词: Molecular biology 、 Biology 、 Akt/PKB signaling pathway 、 Cancer research 、 Protein kinase A 、 Cyclin-dependent kinase 2 、 MAP2K7 、 Cyclin-dependent kinase 4 、 Protein kinase R 、 Squamous carcinoma 、 c-Raf

摘要: … of AKT1 mutation in lung cancer. Our data provide evidence that, although AKT1 mutations are apparently rare in lung … of a fraction of lung carcinoma with squamous histotype (5.5%). …