Antibacterial peptides for therapeutic use: obstacles and realistic outlook.

作者: A MARR , W GOODERHAM , R HANCOCK

DOI: 10.1016/J.COPH.2006.04.006

关键词: AntimicrobialPharmacologyBiologyAntibacterial peptideCationic Antimicrobial PeptidesResistance development

摘要: … For example, IMX00C1, a synthetic peptide with no antibacterial activity in … peptides is arguably the principal problem preventing the widespread clinical use of this class of antibacterial …

参考文章(32)
Victor Nizet, Antimicrobial peptide resistance mechanisms of human bacterial pathogens. Current Issues in Molecular Biology. ,vol. 8, pp. 11- 26 ,(2006)
B. Brett Finlay, Robert E. W. Hancock, Can innate immunity be enhanced to treat microbial infections Nature Reviews Microbiology. ,vol. 2, pp. 497- 504 ,(2004) , 10.1038/NRMICRO908
A.S. Michalopoulos, S. Tsiodras, K. Rellos, S. Mentzelopoulos, M.E. Falagas, Colistin treatment in patients with ICU-acquired infections caused by multiresistant Gram-negative bacteria: the renaissance of an old antibiotic Clinical Microbiology and Infection. ,vol. 11, pp. 115- 121 ,(2005) , 10.1111/J.1469-0691.2004.01043.X
Kim A. Brogden, Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nature Reviews Microbiology. ,vol. 3, pp. 238- 250 ,(2005) , 10.1038/NRMICRO1098
Graham Bell, Pierre-Henri Gouyon, Arming the enemy: the evolution of resistance to self-proteins Microbiology. ,vol. 149, pp. 1367- 1375 ,(2003) , 10.1099/MIC.0.26265-0
Per H. Mygind, Rikke L. Fischer, Kirk M. Schnorr, Mogens T. Hansen, Carsten P. Sönksen, Svend Ludvigsen, Dorotea Raventós, Steen Buskov, Bjarke Christensen, Leonardo De Maria, Olivier Taboureau, Debbie Yaver, Signe G. Elvig-Jørgensen, Marianne V. Sørensen, Bjørn E. Christensen, Søren Kjærulff, Niels Frimodt-Moller, Robert I. Lehrer, Michael Zasloff, Hans-Henrik Kristensen, Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus Nature. ,vol. 437, pp. 975- 980 ,(2005) , 10.1038/NATURE04051
Robert E. W. Hancock, Concerns regarding resistance to self-proteins. Microbiology. ,vol. 149, pp. 3343- 3344 ,(2003) , 10.1099/MIC.0.C0122-0
James P. Tam, Yi-An Lu, Jin-Long Yang, Correlations of Cationic Charges with Salt Sensitivity and Microbial Specificity of Cystine-stabilized β-Strand Antimicrobial Peptides Journal of Biological Chemistry. ,vol. 277, pp. 50450- 50456 ,(2002) , 10.1074/JBC.M208429200
Dawn M.E. Bowdish, Robert E.W. Hancock, Anti-endotoxin properties of cationic host defence peptides and proteins. Journal of Endotoxin Research. ,vol. 11, pp. 230- 236 ,(2005) , 10.1179/096805105X37394