The roles of latency-associated antigens in tuberculosis vaccines.

摘要: Abstract Tuberculosis (TB) is a re-emerging disease and caused by Mycobacterium tuberculosis (M. tuberculosis). TB currently one of the leading causes morbidity mortality, worldwide. The only available vaccine against infection, Bacillus Calmette–Guerin (BCG), fails to adequately protect reactivation latent infections in adults. Furthermore, recently developed subunit vaccines, which are various stages clinical trials, all prophylactic vaccines based on proteins expressed replicating stage M. they not preventive infection. Thus, an appropriate post-exposure needs be control forms To produce multi-stage vaccine, scientists should combine early secreted antigens with latency antigens. For this purpose, some known could important production specific humoral cellular immune responses infected individuals. Several studies have evaluated immunogenicity these improving vaccines. present study comprehensive review several role development Overall, indicate that latency-associated including resuscitation-promoting factors, Dormancy survival regulon (DosR) starvation stimulant potential candidates for