Distinct Amygdalar AMPAergic/GABAergic Mechanisms Promote Anxiolitic-Like Effects in an Unpredictable Stress Model of the Hamster

摘要: Studies have pointed to both α-amino-3-hydroxy-5- methyl-4-isoxazole propionic acid receptor (AMPAR) antago- nists and GABAA (GABAAR) agonists as potent antistress agents. In this work, separate subchronic injections of the AMPAR antagonist, 6-ciano-7-nitroquinoxaline-2,3- dione (CNQX), α1 GABAAR subunit agonist (Zol) within central amygdala nucleus modified elevated plus maze performances hamsters exposed randomly one following stressful conditions: food/water deprivation, forced swimming test, permanence in cold room. Indeed, stressed treated with CNQX or Zol displayed a very great (p<0.001) increase entrance moderate (p<0.05) time spent into open arms, respectively. At cellular level, Zol- animals supplied moderately evident argyrophilic reaction (indicative neurodegeneration) hippocampus while it was absent hypothalamus. Interestingly, significantly reduced by supporting its preferential protective role. Furthermore, agents were responsible for mixed expression pattern GluR1 GluR2 mRNA levels which overall upregulated mRNAs, they downregulated hippocampal oriens-pyramidalis layer III cerebral cortex. These findings support amygdalar AMPAergic response against anxiety states chron- ically hamsters, may constitute useful therapeu- tic strategies panic-related mood disorders.