Cortical morphometric correlational networks associated with cognitive deficits in first episode schizophrenia.
作者： Keith H. Nuechterlein , Kenneth L. Subotnik , Benjamin M. Ellingson , J. Pablo Villablanca , Joseph Ventura
DOI: 10.1016/J.SCHRES.2021.04.001
关键词: Schizophrenia 、 Neuroscience 、 Fusiform gyrus 、 Betweenness centrality 、 Medicine 、 Precuneus 、 Cortical volume 、 First episode schizophrenia 、 Correlation 、 Cognition
摘要: Schizophrenia (SCZ) is a chronic cognitive and behavioral disorder associated with abnormal cortical activity during information processing. Several brain structures the seven performance domains evaluated using MATRICS (Measurement Treatment Research to Improve Cognition in Schizophrenia) Consensus Cognitive Battery (MCCB) have shown volume loss first episode schizophrenia (FES) patients. However, relationship between morphological organization MCCB remains unclear. Therefore, current observational study, high-resolution structural MRI scans were collected from 50 FES patients, morphometric correlation network (MCN) was established characterize pattern poorer performance. We also investigated topological properties, such as modularity, degree betweenness centrality. Our findings show directly strongly deficits of patients precuneus, anterior cingulate, fusiform gyrus, well prefrontal, parietal, sensorimotor cortices. The medial orbitofrontal, fusiform, superior frontal gyri not only identified predominant nodes high centrality MCN, but they found be critical several domains. Together, these results suggest widespread altered that on core pathophysiology SCZ.
sci-hub.st 参考文章(73)
Nancy C. Andreasen, Scale for the Assessment of Negative Symptoms PsycTESTS Dataset. ,(2014) , 10.1037/T12696-000
Monica Juuhl-Langseth, Cecilie B. Hartberg, Aina Holmén, Rune Thormodsen, Inge R. Groote, Lars M. Rimol, Kyrre E. Emblem, Ingrid Agartz, Bjørn R. Rund, Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders PLOS ONE. ,vol. 10, pp. e0130435- ,(2015) , 10.1371/JOURNAL.PONE.0130435
Jessica Cherian, Dylan Atkinson, Krishna R Patel, Kunj Gohil, Schizophrenia: Overview and Treatment Options P & T : a peer-reviewed journal for formulary management. ,vol. 39, pp. 638- 645 ,(2014)
Neeltje E.M. van Haren, Hugo G. Schnack, Martijn G.J.C. Koevoets, Wiepke Cahn, Hilleke E. Hulshoff Pol, René S. Kahn, Trajectories of subcortical volume change in schizophrenia: A 5-year follow-up. Schizophrenia Research. ,vol. 173, pp. 140- 145 ,(2016) , 10.1016/J.SCHRES.2015.09.027
Theo GM van Erp, Derrek P Hibar, Jerod M Rasmussen, David C Glahn, Godfrey D Pearlson, Ole A Andreassen, Ingrid Agartz, Lars T Westlye, Unn K Haukvik, Anders M Dale, Ingrid Melle, Cecilie B Hartberg, Oliver Gruber, Bernd Kraemer, David Zilles, Gary Donohoe, Sinead Kelly, Colm McDonald, Derek W Morris, Dara M Cannon, Aiden Corvin, Marise WJ Machielsen, Laura Koenders, Lieuwe de Haan, Dick J Veltman, Theodore D Satterthwaite, Daniel H Wolf, Ruben C Gur, Raquel E Gur, Steven G Potkin, Daniel H Mathalon, Bryon A Mueller, Adrian Preda, Fabio Macciardi, Stefan Ehrlich, Esther Walton, Johanna Hass, Vince D Calhoun, Henry J Bockholt, Scott R Sponheim, Jody M Shoemaker, Neeltje EM van Haren, HE Hulshoff Pol, Roel A Ophoff, René S Kahn, Roberto Roiz-Santiañez, Benedicto Crespo-Facorro, Lei Wang, Kathryn I Alpert, Erik G Jönsson, Rali Dimitrova, Catherine Bois, Heather C Whalley, Andrew M McIntosh, Stephen M Lawrie, Ryota Hashimoto, Paul M Thompson, JA Turner, None, Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium Molecular Psychiatry. ,vol. 21, pp. 547- 553 ,(2016) , 10.1038/MP.2015.63
Darran Yates, Neurodegenerative networking Nature Reviews Neuroscience. ,vol. 13, pp. 289- 289 ,(2012) , 10.1038/NRN3248
Junghee Lee, Javier Quintana, Poorang Nori, Michael F. Green, Theory of mind in schizophrenia: Exploring neural mechanisms of belief attribution Social Neuroscience. ,vol. 6, pp. 569- 581 ,(2011) , 10.1080/17470919.2011.620774
Y. He, Z. Chen, A. Evans, Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer's disease. The Journal of Neuroscience. ,vol. 28, pp. 4756- 4766 ,(2008) , 10.1523/JNEUROSCI.0141-08.2008
Yuanchao Zhang, Tung-Ping Su, Bing Liu, Yuan Zhou, Kun-Hsien Chou, Chun-Yi Lo, Chia-Chun Hung, Wei-Ling Chen, Tianzi Jiang, Ching-Po Lin, Disrupted thalamo-cortical connectivity in schizophrenia: a morphometric correlation analysis. Schizophrenia Research. ,vol. 153, pp. 129- 135 ,(2014) , 10.1016/J.SCHRES.2014.01.023
Aaron L. Goldman, Lukas Pezawas, Venkata S. Mattay, Bruce Fischl, Beth A. Verchinski, Qiang Chen, Daniel R. Weinberger, Andreas Meyer-Lindenberg, Widespread Reductions of Cortical Thickness in Schizophrenia and Spectrum Disorders and Evidence of Heritability Archives of General Psychiatry. ,vol. 66, pp. 467- 477 ,(2009) , 10.1001/ARCHGENPSYCHIATRY.2009.24