Adhesion molecules in patients after lung transplantation

摘要: Leukocyte adhesion molecules, such as intercellular molecule (ICAM)-1 and its ligands, are involved in inflammatory processes of the lung. For ICAM-1, differential expression during different kinds complications after transplantation has been proposed. We analyzed role CD18, CD11a, CD11b, CD11c episodes rejection or infection patients lung compared results to without apparent complication. A total 98 bronchoalveolar lavage (BAL) samples 90 serum were analyzed. ICAM-1, expressions detected immunocytochemically on alveolar macrophages. Soluble ICAM-1 was quantified BAL. In control group, 49.8±18% macrophages stained positive for CD11b. During rejection, mean cells showing CD11b surface significantly higher (64.6±11.4%), with no difference (59.7±22.7). All other epitopes not expressed differently regard a normal clinical course rejections. In summary, assessment corresponding ligands did allow reliable discrimination between transplantation.