Excretion of indomethacin in breast milk.
作者： P Yapp , MJ Roberts , LP Hackett , LJ Dusci , KF Ilett
DOI: 10.1111/J.1365-2125.1991.TB03984.X
关键词: Excretion 、 Antipyretic 、 Endocrinology 、 Absorption (skin) 、 Pharmacokinetics 、 Chemistry 、 Breast milk 、 Milk intake 、 Analgesic 、 Internal medicine 、 Adverse effect
摘要: 1. The excretion of indomethacin into breast milk and subsequent exposure infants was studied in 16 women seven their infants. median milk:plasma ratio patients where there were measurable drug concentrations both plasma 0.37. 2. Total infant dose, assuming a daily intake 150 ml kg-1 100% absorption, ranged from 0.07% to 0.98% (median = 0.18%) the weight adjusted maternal dose. 3. Plasma samples obtained In six these, below sensitivity assay (less than 20 micrograms l-1), while one had concentration 47 l-1. 4. No adverse effects due reported
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