The effect of clonidine premedication on hemodynamic responses to microlaryngoscopy and rigid bronchoscopy.

摘要: The usual hemodynamic response to laryngoscopy and bronchoscopy is an increase in heart rate arterial blood pressure. Previous work has reported that 10%-18% of the patients develop ischemic ST segment changes during procedure. Therefore, we performed a prospective, randomized, double-blinded study 36 scheduled for elective microlaryngeal bronchoscopic surgical procedures evaluate effects 300-microg oral clonidine premedication (n = 18) or placebo on alterations incidence perioperative myocardial episodes. Myocardial ischemia was assessed by using continuous electrocardiographic monitoring, beginning 30 min before, lasting until 24 h after operation. During procedure, receiving exhibited significant (mean +/- SD) pressure (the systolic increasing from 137+/-11 166+/-17 mm Hg, diastolic 80+/-11 97+/-14 Hg) (increasing 79+/-15 97+/-12 bpm) compared with baseline group. A dose blunted endoscopy. Ventricular arrhythmias were more frequent who not premedicated clonidine. Two control group, but none had evidence ischemia. These data should encourage routine undergoing microlaryngoscopic procedures.