Effects of Photodynamic Therapy on the Growth and Antifungal Susceptibility of Scedosporium and Lomentospora spp.
作者： Qiaoyun Lu , Yi Sun , Dingdan Tian , Shoubao Xiang , Lujuan Gao
DOI: 10.1007/S11046-017-0195-8
关键词: Posaconazole 、 Medical microbiology 、 Voriconazole 、 Biology 、 Minimum inhibitory concentration 、 Photodynamic therapy 、 Microbiology 、 Scedosporium 、 Itraconazole 、 Antimicrobial
摘要: Scedosporium and Lomentospora species are the second most frequent colonizing, allergenic, or invasive fungal pathogens in patients with cystic fibrosis, responsible for infections varying from cutaneous subcutaneous tissue caused by traumatic inoculation to severe systemic diseases immunocompromised patients. The clinical relevance of airway colonization individual harboring is still an underestimated issue. high resistance antifungal drugs has highlighted need alternative treatment modalities, antimicrobial photodynamic therapy may be one such alternative. In this study, methylene blue was applied as a photosensitizing agent 6 type strains species, we irradiated using light-emitting diode (635 ± 10 nm, 12 J/cm2). We evaluated effects on strain growth vitro susceptibility itraconazole, voriconazole, posaconazole, amphotericin B. A colony-forming unit reduction up 5.2 log10 achieved. Minimal inhibitory concentration ranges also decreased significantly photoinactivation. Photodynamic improved both inactivation rates profile all isolates tested.
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