Experimental Autoimmune Encephalomyelitis in the Common Marmoset, a Bridge Between Rodent EAE and Multiple Sclerosis for Immunotherapy Development
作者： Yolanda S. Kap , Jon D. Laman , Bert A. ‘t Hart
DOI: 10.1007/S11481-009-9178-Y
关键词: Experimental autoimmune encephalomyelitis 、 Multiple sclerosis 、 Immunotherapy 、 Myelin oligodendrocyte glycoprotein 、 Interleukin 23 、 Marmoset 、 Neuroscience 、 Central nervous system 、 Immunology 、 Biology 、 Callithrix
摘要: The attrition rate of new drugs for central nervous system diseases including multiple sclerosis (MS) is very high. A widely recognized bottleneck in the selection promising drug candidates from development pipeline lack sufficiently predictive animal models. Here, we review how experimental autoimmune encephalomyelitis (EAE) model Neotropical primate “common marmoset” can help to bridge gap between rodent EAE models and MS. marmoset closely resembles MS clinical as well pathological presentation be used fundamental research into immunopathogenic mechanisms therapy development. We discuss recent insights arising this model, both on novel therapeutics immunopathogenesis.
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sci-hub.se 参考文章(66)
Claude P. Genain, Stephen L. Hauser, Experimental allergic encephalomyelitis in the New World monkey Callithrix jacchus. Immunological Reviews. ,vol. 183, pp. 159- 172 ,(2001) , 10.1034/J.1600-065X.2001.1830113.X
Herbert P. M. Brok, Marjan van Meurs, Erwin Blezer, Allen Schantz, David Peritt, George Treacy, Jon D. Laman, Jan Bauer, Bert A. ’t Hart, Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody. Journal of Immunology. ,vol. 169, pp. 6554- 6563 ,(2002) , 10.4049/JIMMUNOL.169.11.6554
Alemtuzumab vs. interferon beta-1a in early multiple sclerosis. The New England Journal of Medicine. ,vol. 359, pp. 1786- 1801 ,(2008) , 10.1056/NEJMOA0802670
Ismail Kola, John Landis, Can the pharmaceutical industry reduce attrition rates? Nature Reviews Drug Discovery. ,vol. 3, pp. 711- 716 ,(2004) , 10.1038/NRD1470
Bert A. 't Hart, Jan Bauer, Henk-Jan Muller, Bert Melchers, Klaas Nicolay, Herbert Brok, Ronald E. Bontrop, Hans Lassmann, Luca Massacesi, Histopathological Characterization of Magnetic Resonance Imaging-Detectable Brain White Matter Lesions in a Primate Model of Multiple Sclerosis The American Journal of Pathology. ,vol. 153, pp. 649- 663 ,(1998) , 10.1016/S0002-9440(10)65606-4
Yolanda S. Kap, Paul Smith, S. Anwar Jagessar, Ed Remarque, Erwin Blezer, Gustav J. Strijkers, Jon D. Laman, Rogier Q. Hintzen, Jan Bauer, Herbert P. M. Brok, Bert A. ‘t Hart, Fast Progression of Recombinant Human Myelin/Oligodendrocyte Glycoprotein (MOG)-Induced Experimental Autoimmune Encephalomyelitis in Marmosets Is Associated with the Activation of MOG34–56-Specific Cytotoxic T Cells Journal of Immunology. ,vol. 180, pp. 1326- 1337 ,(2008) , 10.4049/JIMMUNOL.180.3.1326
Hugh I McFarland, Adrian A Lobito, Michele M Johnson, Jeffrey T Nyswaner, Joseph A Frank, Gregory R Palardy, Nancy Tresser, Claude P Genain, John P Mueller, Louis A Matis, Michael J Lenardo, None, Determinant Spreading Associated with Demyelination in a Nonhuman Primate Model of Multiple Sclerosis Journal of Immunology. ,vol. 162, pp. 2384- 2390 ,(1999)
Jan D. Lünemann, Christian Münz, EBV in MS: guilty by association? Trends in Immunology. ,vol. 30, pp. 243- 248 ,(2009) , 10.1016/J.IT.2009.03.007
Erwin L. A. Blezer, Jan Bauer, Herbert P. M. Brok, Klaas Nicolay, Bert A. 't Hart, Quantitative MRI-pathology correlations of brain white matter lesions developing in a non-human primate model of multiple sclerosis. NMR in Biomedicine. ,vol. 20, pp. 90- 103 ,(2007) , 10.1002/NBM.1085
Bert A. 't Hart, Jan Bauer, Herbert P.M. Brok, Sandra Amor, Non-human primate models of experimental autoimmune encephalomyelitis: Variations on a theme Journal of Neuroimmunology. ,vol. 168, pp. 1- 12 ,(2005) , 10.1016/J.JNEUROIM.2005.05.017