High Prevalence of RAS Mutations in RET-Negative Sporadic Medullary Thyroid Carcinomas

作者: Margarida M. Moura , Branca M. Cavaco , António E. Pinto , Valeriano Leite

DOI: 10.1210/JC.2010-1921

关键词: EndocrinologyCancerMedullary cavityCarcinogenesisHigh prevalenceMedicineInternal medicineThyroid carcinoma

摘要: High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas (MTC) suggests that activation these protooncogenes represent alternative genetic events MTC tumorigenesis.

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