Oscillations in the proximal intratubular pressure: a mathematical model.

摘要: This study presents a dynamic continuous time model of the regulation renal proximal intratubular pressure in rat. The integrates functional glomerulus, tubular model, feedback and an afferent arteriolar model. has one equilibrium solution for dependent variables (equilibrium point) each set independent variables. An point, chosen to be accordance with experimental data from Sprague-Dawley rats, was used as initial value is shown have parameter ranges which sustained stable oscillations are present. For appear, it necessary system's operating point located on sufficiently steep portion tubuloglomerular curve. analyses compared various recordings pressure. simulations show both spontaneous induced ...