Pharmacodynamics of pentoxifylline and/or praziquantel in murine schistosomiasis mansoni.

摘要: Pentoxifylline (PTX) was proved to exert both anti-inflammatory and anti-fibrotic effects, used therapeutically in this experimental model investigate its role alone or with praziquantel (PZQ) Schistosoma mansoni-infected mice, explore impact on the tissue expression of transforming growth factor-beta1 (TGF-beta1). S. mice were divided into seven groups: Control untreated (I), treated curative dose PZQ, 500 mg/kg/day for 2 consecutive days (II), subcurative dose, 100 (III), PTX (10 5 days/wk) 4 weeks (IV) addition PZQ (V), 8 (VI) (VII). All animals killed 10 post infection. Parasitological assessment worm burden, egg load oogram pattern carried out. The degree granulomatous fibrosis eosinophilic cell population quantified Sirius-red-stained sections factor beta-1 estimated immunohistochemically. Serum ALAT GGT, as well hepatic content reduced GSH, measured. results revealed highest percent reduction dead ova groups (II) (VII) accompanied by significant diminution parameters, collagen TGF-beta1 expression. Moreover, treatments and/or ameliorated liver functions. In conclusion, prolonged treatment has a potent anti-fibrogenic especially when early stages infection, limited toxic effects schistosome worms eggs. Thus, can be an adjuvant therapeutic tool anti-helminthic drugs human schistosomiasis.