Lipidomics Reveals a Tissue-Specific Fingerprint.
作者： Irene Pradas , Kevin Huynh , Rosanna Cabré , Victòria Ayala , Peter J. Meikle
关键词: White adipose tissue 、 Organelle 、 Biochemistry 、 Chemistry 、 Sphingolipid 、 Lipidomics 、 Sterol 、 Glycerophospholipid 、 Membrane lipids 、 Cholesterol
摘要: In biological systems lipids generate membranes and have a key role in cell signaling energy storage. Therefore, there is wide diversity of molecular lipid expressed at the compositional level organelles, as well tissues, whose distribution remains unclear. Here, we report mass spectrometry study abundance across 7 rat detecting quantifying 652 species from glycerolipid, glycerophospholipid, fatty acyl, sphingolipid, sterol prenol categories. Our results demonstrate that every tissue analyzed presents specific concentration. Thus, glycerophospholipids are most abundant lipid, they share similar but differ particular between tissues. Sphingolipids more concentrated renal cortex can be found mainly both liver kidney. Both types white adipose tissue, visceral subcutaneous, rich glycerolipids differing amount. Acylcarnitines skeletal muscle, gluteus soleus, while heart higher levels ubiquinone than other The present demonstrates existence tissue-specific fingerprint.
frontiersin.org
sci-hub.se 参考文章(52)
Tingting Zhang, Si Chen, Xinle Liang, Hong Zhang, Development of a mass-spectrometry-based lipidomics platform for the profiling of phospholipids and sphingolipids in brain tissues Analytical and Bioanalytical Chemistry. ,vol. 407, pp. 6543- 6555 ,(2015) , 10.1007/S00216-015-8822-Z
Colin H. Cortie, Anthony J. Hulbert, Sarah E. Hancock, Todd W. Mitchell, Darryl McAndrew, Paul L. Else, Of mice, pigs and humans: An analysis of mitochondrial phospholipids from mammals with very different maximal lifespans Experimental Gerontology. ,vol. 70, pp. 135- 143 ,(2015) , 10.1016/J.EXGER.2015.08.011
Gwendolyn Barceló-Coblijn, José A. Fernández, Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge. Frontiers in Physiology. ,vol. 6, pp. 3- 3 ,(2015) , 10.3389/FPHYS.2015.00003
Daniel Segré, Dafna Ben-Eli, David W. Deamer, Doron Lancet, The lipid world. Origins of Life and Evolution of Biospheres. ,vol. 31, pp. 119- 145 ,(2001) , 10.1023/A:1006746807104
Genovefa Kolovou, Vana Kolovou, Sophie Mavrogeni, Lipidomics in vascular health: current perspectives. Vascular Health and Risk Management. ,vol. 11, pp. 333- 342 ,(2015) , 10.2147/VHRM.S54874
Zahir Alshehry, Christopher Barlow, Jacquelyn Weir, Youping Zhou, Malcolm McConville, Peter Meikle, An Efficient Single Phase Method for the Extraction of Plasma Lipids Metabolites. ,vol. 5, pp. 389- 403 ,(2015) , 10.3390/METABO5020389
C.M. Paleos, A decisive step toward the origin of life Trends in Biochemical Sciences. ,vol. 40, pp. 487- 488 ,(2015) , 10.1016/J.TIBS.2015.06.001
Daisuke Hishikawa, Tomomi Hashidate, Takao Shimizu, Hideo Shindou, Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells Journal of Lipid Research. ,vol. 55, pp. 799- 807 ,(2014) , 10.1194/JLR.R046094
Christian Klose, Michal A Surma, Kai Simons, Organellar lipidomics — background and perspectives Current Opinion in Cell Biology. ,vol. 25, pp. 406- 413 ,(2013) , 10.1016/J.CEB.2013.03.005
Susanne E. Horvath, Günther Daum, Lipids of mitochondria. Progress in Lipid Research. ,vol. 52, pp. 590- 614 ,(2013) , 10.1016/J.PLIPRES.2013.07.002