Autologous Bone Marrow Transplantation in Multiple Sclerosis: Biomarker Relevance for Patient Recruitment and Follow up.

摘要: Background: Despite the current availability of disease modifying therapies for treatment multiple sclerosis, there are still patients who suffer from severe neurological dysfunction in relapsing-remitting or early progressive forms disease. For these autologous hematopoietic stem cell transplant offers an important therapeutic solution to prevent progression irreversible disability. In spite studies last two decades, patient inclusion criteria, protocols peripheral blood mobilization and bone marrow conditioning methodology follow up sclerosis have not been strictly unified. Methods: We reviewed five recent clinical that confirmed positive outcome disclosing significant differences enrollment including subtypes, duration range, disability, regimens conditioning, scheduling imaging after transplant, absence laboratory biomarkers consistently applied studies. Results: Therapy with has shown best results among young individuals through its ability maintain no evidence activity status a significantly higher proportion comparison treated therapies. Important cross-sectional were found. Conclusion: A specific careful selection biomarkers, based on physiopathological mechanisms known result will contribute better earlier process. An objective measurable response could be obtained determination at onset follow-up reconstitution immune response. The application such parameters also help further our understanding pathogenesis