Mortality Among People With HIV Treated for Tuberculosis Based on Positive, Negative, or No Bacteriologic Test Results for Tuberculosis: The IeDEA Consortium.

摘要: Background In resource-constrained settings, many people with HIV (PWH) are treated for tuberculosis (TB) without bacteriologic testing. Their mortality compared those testing is uncertain. Methods We conducted an observational cohort study among PWH ≥15 years of age initiating TB treatment at sites affiliated 4 International epidemiology Databases to Evaluate AIDS consortium regions from 2012 2014: Caribbean, Central and South America, Central, East, West Africa. The exposure interest was the test status initiation: positive, negative, or no result. hazard death in 12 months after initiation estimated using a Cox proportional model. Missing covariate values were multiply imputed. Results 2091 PWH, median 36 years, 53% had CD4 counts ≤200 cells/mm3, 52% on antiretroviral therapy (ART) initiation. adjusted higher patients positive results (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.08-2.26). also negative tests but not statistically significant (HR, 1.28; CI, 0.91-1.81). Being ART, having count, tertiary facility level associated lower death. Conclusions There some evidence that PWH risk than tests. Research needed understand causes