Hantaviruses: history and overview.

摘要: As early as 1913, Russian clinical records from far eastern Siberia describe the human viral disease now known hemorrhagic fever with renal syndrome (HFRS) (Casals et al. 1970). Dr. Ho Wang Lee (1982) found a Chinese medical account of similar dating to about A.D. 960. This is not surprising in view its unique complication and fact that etiologic agent HFRS proved be zoonotic virus causes chronic infection urinary excretion murid rodent, Apodemus agrarius. mouse most common wild rodent over much northern Asia often invades cultivated fields, gardens, haystacks, sometimes dwellings. Human conflict during lethal 20th century also played prominent role elucidation etiology, evolution, epidemiology, ecology HFRS. “Field nephritis”, which occurred both allied German troops Flanders World War I, may well have been caused by hantavirus occur western Europe Scandinavia (Bradford 1916; Arnold 1944). Japanese military physicians encountered mid 1930s after invading Manchuria (Kitano 1944), Finnish soldiers were affected II (Stuhlfauth 1943; Hortung UN first original Korean Conflict 1951 (Smadel 1953).