Phosphatidylinositol Kinase, a Key Enzyme of Phosphatidylinositol Metabolism: Its Role in an Intracellular Second Messenger System
作者： Zafiroula Georgoussi , Ludwig M. G. Heilmeyer
DOI: 10.1007/978-1-4684-4979-2_4
关键词: Phosphatidylinositol 、 Phosphoinositide-dependent kinase-1 、 Kinase 、 Biochemistry 、 Akt/PKB signaling pathway 、 Second messenger system 、 Pleckstrin homology domain 、 PLCB2 、 Chemistry 、 Calmodulin
摘要: It is now well established that many cell agonists, hormones or neurotransmitters called “first messengers” provoke intracellulary a concentration change of “second messenger” like cyclic AMP, GMP Ca2+ (for review: Dumont et al., 1981), (Fig. 1). An increase these second messengers leads to saturation specific receptor proteins which can be either regulatory domains enzymes in case Ca2+, binding proteins, e. g. calmodulin.
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