The Quest for an Effective Treatment for an Intractable Cancer: Established and Novel Therapies for Pancreatic Adenocarcinoma.

摘要: With therapies that date back to the 1950s, and few newly approved treatments in last 20 years, pancreatic cancer remains a significant challenge for development of novel therapeutics. Current regimens have successfully extended patient survival, although they still lead prognoses measured months rather than years. The genetic diversity inherent tumors forms roadblocks must be overcome future Recent insight into patterns found tumor cells may provide clues leading better understanding challenges hindering treatments. Here, we review currently used drugs established combination comprise standard care highly recalcitrant disease. Novel approaches can improve upon current variety ways. Enhancing specificity, such growth inhibition cytotoxic effects act preferentially on cells, is one approach advance This accomplished through targeting extracellular markers specific cells. Additionally, enlisting natural defenses overcoming tumor-driven immune suppression could prove useful tactic. studies utilizing these yielded promising results contribute an ongoing effort battling particularly difficult cancer.