Longevity and aging: beneficial effects ofexposure to mild stress
作者： Nadège Minois
关键词: Beneficial effects 、 Longevity 、 Physiology 、 Fight-or-flight response 、 Hypergravity 、 Mild stress 、 Toxicology 、 Biology 、 Metabolic regulation 、 Geriatrics gerontology
摘要: Every organism has to deal with exposure stresses.Animals have developed various strategies cope stress. It appears that the resistanceto stress is often related longevity. Somescientists advanced hypothesis thestress response may also counteract negativeeffects of aging, and exposing organisms amild, sublethal stress, inducing a response,may help them live longer. Several mild stresseshave been reported increase longevity (irradiation,heat cold shock, hypergravity, exercise, etc.), andone them, decrease rate ofbehavioral aging. The mechanisms whereby thesestresses not yet elucidated.However, studies conducted so far show theymay involve metabolic regulation protein(hsps) induction.
springer.com
sci-hub.se 参考文章(128)
Amy S. Resler, Amy S. Resler, Kristi Kelly, Kristi Kelly, Geri Kantor, Aziz A. Khazaeli, Marc Tatar, Marc Tatar, James W. Curtsinger, Genetic analysis of extended life span in Drosophila melanogaster. II. Replication of the backcross test and molecular characterization of the N14 locus. Genetica. ,vol. 104, pp. 33- 39 ,(1998) , 10.1023/A:1003420625925
R. S. Sohal, The Rate of Living Theory: A Contemporary Interpretation Springer Berlin Heidelberg. pp. 23- 44 ,(1986) , 10.1007/978-3-642-70853-4_3
George A. Sacher, Effects of X-Rays on the Survival of Drosophila imagoes Physiological Zoology. ,vol. 36, pp. 295- 311 ,(1963) , 10.1086/PHYSZOOL.36.4.30152744
Katsuhiro Tamura, Mitsuo Miyashita, Hitoshi Iwahashi, Stress tolerance of pressure-shocked Saccharomyces cerevisiae Biotechnology Letters. ,vol. 20, pp. 1167- 1169 ,(1998) , 10.1023/A:1005388722750
Panov S, Weber L, Walford Rl, Caloric restriction and aging as viewed from Biosphere 2. Receptor. ,vol. 5, pp. 29- 33 ,(1995)
James W. Curtsinger, Hank H. Fukui, Amy S. Resler, Kristi Kelly, Aziz A. Khazaeli, Genetic analysis of extended life span in Drosophila melanogaster. I. RAPD screen for genetic divergence between selected and control lines. Genetica. ,vol. 104, pp. 21- 32 ,(1998) , 10.1023/A:1003442619700
Vladimir Veniaminovich Frolkis, Aging and Life-Prolonging Processes ,(1983)
J. Oyama, Metabolic effects of hypergravity on experimental animals ,(1982)
A. Y.-C. Liu, Y.-K. Lee, D. Manalo, L. E. Huang, Attenuated heat shock transcriptional response in aging: molecular mechanism and implication in the biology of aging. EXS. ,vol. 77, pp. 393- 408 ,(1996) , 10.1007/978-3-0348-9088-5_26
Éric Le Bourg, Nadège Minois, A mild stress, hypergravity exposure, postpones behavioral aging in Drosophila melanogaster. Experimental Gerontology. ,vol. 34, pp. 157- 172 ,(1999) , 10.1016/S0531-5565(98)00077-1