The investigation of EEG specificity in epileptic children during Depakine therapy
作者： Irma Khachidze , Manana Gugushvili , Malkhaz Makashvili , Victor Maloletnev
DOI: 10.3109/00207454.2015.1083991
关键词: Valproic Acid 、 Epileptic discharge 、 Epilepsy 、 Brain mapping 、 Interictal eeg 、 Antiepileptic drug 、 Electroencephalography 、 Psychology 、 Anesthesia 、 Sharp wave
摘要: Background: Antiepileptic drug (AED) therapy in epileptic children can be optimized via an anticipation of AED efficacy during early stages therapy. We hypothesize that the comprehensive electroencephalography (EEG) evaluation determine children. Thus, this study aimed to investigate alteration characteristics interictal EEG Methods: Forty-three aged 3–9 were investigated. EEGs recorded three times: prior valproic acid-Depakine (Dep) monotherapy and twice under Dep (at six/eight months). Baseline was analyzed for quantitative EEG, such as absolute values power (AVP) spectra topography/brain mapping. The involved epileptiform clinical condition assessments. Results: decreased AVP a low-frequency range, suppressed spontaneous discharge, spike-wave complex 3/s. partially spikes-polyspikes, sharp wave...
medicom-mtd.com 参考文章(48)
Anders Hedström, Ingrid Olsson, Epidemiology of absence epilepsy: EEG findings and their predictive value Pediatric Neurology. ,vol. 7, pp. 100- 104 ,(1991) , 10.1016/0887-8994(91)90004-5
X. Wu, C.H. Xiao, Quantitative pharmaco-EEG of carbamazepine in volunteers and epileptics Clinical Eeg and Neuroscience. ,vol. 27, pp. 40- 45 ,(1996) , 10.1177/155005949602700107
Michael R. Trimble, Pamela J. Thompson, Sodium valproate and cognitive function. Epilepsia. ,vol. 25, ,(1984) , 10.1111/J.1528-1157.1984.TB05640.X
Lineu C. Fonseca, Glória M.A.S. Tedrus, Marcelo G. Chiodi, Jaciara Näf Cerqueira, Marcos Henrique Coelho Duran, Eletrencefalograma quatitativo em crianças com epilepsia benigna da infância com pontas centrotemporais: análise de freqüências Arquivos De Neuro-psiquiatria. ,vol. 62, pp. 455- 458 ,(2004) , 10.1590/S0004-282X2004000300014
Mario Rodriguez, Alfonso Reyes, Catalina Rocha, Thalia Harmony, Guillermo Hinojosa, Erzsebet Marosi, Jacqueline Becker, Correlation Between Eeg Spectral Parameters and an Educational Evaluation International Journal of Neuroscience. ,vol. 54, pp. 147- 155 ,(1990) , 10.3109/00207459008986630
Roland Besser, Klaus Hornung, Martin Theisohn, Gerhard Rothacher, Günter Krämer, EEG changes in patients during the introduction of carbamazepine. Electroencephalography and Clinical Neurophysiology. ,vol. 83, pp. 19- 23 ,(1992) , 10.1016/0013-4694(92)90128-5
H. Caspers, Electroencephalography: Basic Principles, Clinical Applications and Related Fields. Ernst Niedermeyer , Fernando Lopes da Silva The Quarterly Review of Biology. ,vol. 58, pp. 301- 302 ,(1983) , 10.1086/413356
Pierre Genton, Joe McMenamin, Aggravation of Seizures by Antiepileptic Drugs: What to Do in Clinical Practice Epilepsia. ,vol. 39, ,(1998) , 10.1111/J.1528-1157.1998.TB05119.X
D. Schmidt, W. Löscher, Uncontrolled epilepsy following discontinuation of antiepileptic drugs in seizure-free patients: a review of current clinical experience. Acta Neurologica Scandinavica. ,vol. 111, pp. 291- 300 ,(2005) , 10.1111/J.1600-0404.2005.00408.X
Luigi M Specchio, Ettore Beghi, Should antiepileptic drugs be withdrawn in seizure-free patients? CNS Drugs. ,vol. 18, pp. 201- 212 ,(2004) , 10.2165/00023210-200418040-00001