Effect of pore size and spacing on neovascularization of a biodegradble shape memory polymer perivascular wrap

作者: Timothy C. Boire , Lauren E. Himmel , Fang Yu , Christy M. Guth , Bryan R. Dollinger

DOI: 10.1002/JBM.A.37021

关键词: MicrovesselNeointimal hyperplasiaImplantBiomedical engineeringPore sizeShape-memory polymerClinical successMaterials scienceMicroporous materialNeovascularization

摘要: Neointimal hyperplasia (NH) is a main source of failures in arteriovenous fistulas and vascular grafts. Several studies have demonstrated the promise perivascular wraps to reduce NH via promotion adventitial neovascularization providing mechanical support. Limited clinical success thus far may be due inappropriate material selection (e.g., nondegradable, too stiff) geometric design pore size spacing, diameter). The influence spacing on implant investigated here for new biodegradable, thermoresponsive shape memory polymer (SMP) wrap. Following an initial pilot, 21 mice were each implanted with six scaffolds: four candidate SMP macroporous designs (a-d), nonporous control (e), microporous GORETEX (f). Mice sacrificed after 4 (N = 5), 14 8), 28 8) days. There was statistically significant increase score between all groups compared (p < .023) .007) controls at Day 28. Wider-spaced, smaller-sized (223 μm-spaced, 640 μm-diameter Design c) induced most robust angiogenic response, greater microvessel number .0114) area .0055) than SMPs This also produced significantly density 0.0028) smaller-spaced, larger-sized (155 1,180 μm-sized b) .0013). Strong expected NH, motivating further investigation this wrap controlled more advanced models.

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