Factors associated with cognitive impairment during the first year of treatment for nonmetastatic breast cancer.

摘要: BACKGROUND Women with breast cancer are more likely to develop cognitive impairment (CI), insomnia, fatigue, and mood disturbance than individuals other cancers. The main objectives of this study were establish the prevalence CI examine relationships between CI, over first year treatment. METHODS Participants recruited after diagnosis completed validated measures objective perceived at four time points during A random intercepts cross-lagged panel model assessed among symptoms time. RESULTS sample included 98 women. Prevalence ranged from 3.1% 8.2% throughout year, whereas 36.7% demonstrated a clinically meaningful decline in baseline 4 months, which remained relatively stable. Greater was associated fatigue (β = -0.78, z = 17.48, p < .01) insomnia (β = -0.58, z = 5.24, p < .01). Short-term fluctuations (p < .05), but not or predicted future CI. Fatigue (p < .001) significant predictor reported insomnia. CONCLUSION Subjective is prevalent impairments. Fatigue, remain stable Changes may have little effect on cognition. require targeted intervention for these side effects.