Measurement of plasma 5-hydroxyindoleacetic acid in carcinoid disease: an alternative to 24-h urine collections?
作者： T J Degg , K R Allen , J H Barth
关键词: Reference values 、 Carcinoid syndrome 、 5-Hydroxyindoleacetic acid 、 Excretion 、 Dietary Requirements 、 Isocratic hplc 、 Chemistry 、 24 h urine 、 Chromatography 、 Urine
摘要: The biochemical investigation of carcinoid disease has relied on measurement the daily excretion 5-hydroxyindoleacetic acid (5HIAA) in urine. 1 Collection 24-h urine considerable disadvantages for patient. Inconvenience, embarrassment, strict dietary requirements and need hazardous preservatives make this test unpopular, signi® cant errors collection may be made. 5-HIAA plasma would offer a more convenient alternative. However, value measurements not been evaluated. Highperformance liquid chromatographic (HPLC) methods measuring have described previously, but applied to patients with psychiatric neurological disorders. 2 We describe simple, isocratic HPLC method
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