Efficacy of antipsychotics for irritability and aggression in children: a meta-analysis.
作者： Gerrit I. van Schalkwyk , Alan S. Lewis , Chad Beyer , Jessica Johnson , Samuel van Rensburg
DOI: 10.1080/14737175.2017.1371012
关键词: Risperidone 、 Internal medicine 、 Irritability 、 Psychology 、 Psychiatry 、 Aripiprazole 、 Subgroup analysis 、 Sedation 、 Antipsychotic 、 Poison control 、 Aggression
摘要: ABSTRACTBackground: Aggression and irritability in children occur across a range of diagnoses, are associated with both economic cost negative psychosocial outcomes. Antipsychotics frequently prescribed these cases.Methods: A random effects meta-analysis 14 controlled trials was conducted. Overall effect sizes for antipsychotics aggression were extracted. Subgroup analyses conducted according to diagnostic indication, specific medication degree sedation. Meta-regression examined antipsychotic dose.Results: Overall, effective reducing (SMD = 0.74, 95% confidence interval [CI] 0.57–0.92, z = 8.4, p < 0.0001). In stratified subgroup analysis, individual agents did not differ efficacy (χ2 = 1.1, df = 3, p = 0.78). However, aripiprazole risperidone demonstrated significant benefit over placebo. Antipsychotic significantly based on indica...
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