Arterial first pass gadolinium-CM dynamics as a function of several intravenous saline flush and Gd volumes.

摘要: This study was performed to evaluate the dynamics of an arterial first pass gadolinium (Gd) contrast medium (CM) bolus at descending aorta (DAo), depending on various saline flush and Gd volumes. Using ultra-fast two- dimensional GE-sequence (Siemens Vision®, 1.5-T), 200 sequential cross-sectional images addressed vessel (1 slice/s) were obtained. Several volumes (15 mL, 30 60 mL) applied following administration 10 mL (single dose) a group 4 normal volunteers (body weight 50–55 kg) using mechanical MR injector (injection rate = 3.0 mL/s). Additionally, when performing second test series, volume remained constant, while varied from half doses triple (5, 10, 20, given every volunteer group). The signal intensity versus time (SI/T) curve measured region interest (ROI) within DAo calculated. arrival (BAT), maximal signal-to-noise ratio (SNRmax), length (BL; 75% 80% maximum duration), slope SI/T curve, areas below for both duration level (INT80% INT75%) increase caused significant lengthening approximately 50% (mean BL 9.5 s, 10.3 15.4 s 15 volumes, respectively, as SNRmax level). equal or higher than increased curve. A continuous INT75%/80% by found. Different did not affect BAT. Only low dose (0.05 mmol/kg Gd) showed 17%–21.6% significantly lower SNRmax. INT mainly enlarging single double (BL75% INT75% 9.6 1305, 12.3 2121, 38.5 6181, 37.8 6613 5, volume, respectively). benefits increasing due venous wash out effects injection site vein. Doses larger are needed SNR in contrast-enhanced magnetic resonance angiography thoracic aorta. J. Magn. Reson. Imaging 2001;13:568–576. © 2001 Wiley-Liss, Inc.