Interleukin‐21 induces migration and invasion of fibroblast‐like synoviocytes from patients with rheumatoid arthritis

摘要: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone erosion. Fibroblast-like synoviocytes (FLS) play pivotal role in RA pathogenesis through aggressive migration matrix invasion, certain proinflammatory cytokines may affect synoviocyte invasion. Whether interleukin (IL)-21 influences this process remains controversial. Here, we evaluated the potential regulatory effect of IL-21 on migration, invasion metalloproteinase (MMP) expression RA-FLS. We found that promoted MMP (MMP-2, MMP-3, MMP-9, MMP-13) production Moreover, induced activation phosphoinositide 3-kinase (PI3K), signal transducer activator transcription-3 (STAT-3) extracellular signal-regulated protein kinases 1 2 (ERK1/2) pathways, blockage these pathways [PI3K/protein kinase B (AKT) inhibitor LY294002, STAT-3 STA-21 ERK1/2 PD98059] attenuated IL-21-induced secretion MMP-3 MMP-9. In conclusion, our results suggest promotes Therefore, therapeutic strategies targeting might be effective for treatment RA.