Update on the role of antipsychotics in the treatment of Tourette syndrome.

摘要: Tourette syndrome (TS) is a neuropsychiatric disorder with typical onset in childhood and characterized by chronic occurrence of motor vocal tics. The can lead to serious impairments both quality life psychosocial functioning, particularly for those individuals displaying complex In such patients, drug treatment recommended. pathophysiology TS thought involve dysfunction basal ganglia-related circuits hyperactive dopaminergic innervations. Congruently, dopamine receptor antagonism neuroleptics appears be the most efficacious approach pharmacological intervention. To assess efficacy different available, systematic, keyword-related search PubMed (National Library Medicine, Washington, DC) was undertaken. Much information on use antipsychotics based older data. Our objective give an update therefore we focused papers published last decade (between 2001 2011). Accordingly, present review aims summarize current evidence-based knowledge risk-benefit ratio first second generation TS.