Association of esophagitis and esophageal strictures with diseases treated with nonsteroidal anti-inflammatory drugs.

摘要: Background It has been speculated that intake of nonsteroidal anti-inflammatory drugs (NSAIDs) represents a risk factor for the occurrence esophagitis and esophageal strictures. Methods A case-control study was conducted to compare comorbid diseases treated with NSAIDs in case control subjects without disease, respectively. The population comprised all patients (International Classification Diseases code 530.1) or stricture (code 530.3) who were discharged from hospitals Department Veteran Affairs between 1981 1994. In separate multivariate logistic regressions, served as outcome variable, age, gender, ethnicity, an NSAID-related diagnosis modifier variables. Results total 101,366 individual included, whom 92,860 presented 14,201 stricture. erosive associated osteoarthritis (odds ratio = 1.42, 95% confidence interval 1.36-1.48), osteoporosis (1.38, 1.25-1.52), back pain (1.49, 1.42-1.56), femur bone fracture (1.46, 0.92-2.32), fibrositis (1.57, 1.41-1.75), tension headache (1.34, 1.27-1.40), ankylosing spondylitis (1.33, 1.24-1.42), rheumatoid arthritis (1.13, 1.05-1.21), sicca syndrome (1.15, 1.05-1.26), systemic sclerosis (6.16, 4.65-8.14). diagnoses represented similar factors both Conclusions large variety by are significantly increased erosion stricture; appears these. some conditions, underlying disease process may contribute pathology.