Targeting Viral Antigens for the Treatment of Malignancies
作者： Gretchen L. Eiben , Diane M. Da Silva , Steven C. Fausch , Amanda M. Krier , I. Caroline Le Poole
DOI: 10.1007/978-1-59259-680-5_5
关键词: Biology 、 Cancer 、 Hepatitis B 、 Hepatitis C 、 Vaccination 、 Human leukocyte antigen 、 Virology 、 Venezuelan equine encephalitis virus 、 Lymphoma 、 Virus
摘要: Viruses implicated in the development of human cancer include hepatitis B (HBV) and C (HCV) viruses, papilloma virus (HPV), Epstein-Barr (EBV), T-cell lymphoma virus, herpes 8. Together they contribute significantly to total incidence worldwide. Current work each these systems seeks understand mechanisms viral action identify strategies immune intervention combat infection subsequent transformation. It is thought that oncogenic proliferation may be instigated by presence expression oncogenes, which integrated into host genome. Critical genes also interfere with genes, resulting activation cellular proto-oncogenes and/or inactivation anti-oncogenes their products. Targeting such proteins through various vaccination offers both therapeutic prophylactic against induced malignancies.
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