CONTROLLED TRIAL OF SOTALOL FOR ONE YEAR AFTER MYOCARDIAL INFARCTION
作者： D.G. Julian , F.S. Jackson , R.J. Prescott , P. Szekely
DOI: 10.1016/S0140-6736(82)92225-5
关键词: Infarction 、 Placebo group 、 Myocardial infarction 、 Beta adrenoceptor 、 Randomized controlled trial 、 Placebo 、 Anesthesia 、 Sotalol 、 Mortality rate 、 Cardiology 、 Internal medicine 、 Medicine
摘要: In a multicentre double-blind randomised study, the effect of sotalol 320 mg once daily was compared with that placebo in patients surviving an acute myocardial infarction. Treatment started 5--14 days after infarction 1456 (60% being to sotalol, and 40% placebo) who represented 45% those evaluated for entry. Patients were followed 12 months. The mortality rate 7.3% (64 patients) group 8.9% (52 group. 18% lower than group, but this difference not statistically significant. definite reinfarction 41% (p less 0.05). Although differences significant, trial supports evidence that, year infarction, beta adrenoceptor blocking drugs reduce by 20--25%.
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