Transdermal delivery of forskolin from emulsions differing in droplet size.
作者： Elżbieta Sikora , Meritxell Llinas , Maria Jose Garcia-Celma , Elvira Escribano , Conxita Solans
DOI: 10.1016/J.COLSURFB.2015.01.008
关键词: High-performance liquid chromatography 、 Permeation 、 Coleus 、 Chromatography 、 Ethanol 、 Human skin 、 Forskolin 、 Transdermal 、 Penetration (firestop) 、 Chemistry
摘要: Abstract The skin permeation of forskolin, a diterpene isolated from Coleus forsholii , was studied using oil in water (O/W) emulsions as delivery formulations and also an solution for comparative purposes. Two forskolin-loaded water/Brij 72:Symperonic A7/Miglyol 812:Isohexadecane, at 0.075 wt% forskolin concentration were prepared with the same composition only differing droplet size (0.38 μm 10 μm). showed high kinetic stability 25 °C. In vitro study penetration through human carried out MicroettePlus ® system. active receptor ( i.e. ethanol/phosphate buffer 40/60, v/v) analyzed by performance liquid chromatography UV detection. obtained results that solution, skin, very (up to 72.10%), no effect observed.
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