Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics.

摘要: The ErbB signaling network instructs the execution of key cellular programs, such as cell survival, proliferation and motility, through generation robust signals defined strength duration. In contrast, unabated disrupts tissue homeostasis leads to transformation. Cells oppose threat inherent in excessive activity several mechanisms negative feedback regulation. Inducible inhibitors (IFIs) are expressed context transcriptional responses triggered by signaling, thus being uniquely suited regulate during complex programs. This review focuses on MIG6, an IFI that restrains mediating kinase suppression receptor down-regulation. We will issues MIG6 function, regulation tumor suppressor activity. Subsequently, role for loss pathogenesis tumors driven oncogenes well addiction be discussed. conclude analyzing inhibition therapies directed against non-ErbB oncogenes.