Potential Roles of BMP9 in Liver Fibrosis
作者： Jianjun Bi , Shengfang Ge
关键词: Cancer research 、 Hepcidin 、 Signal transduction 、 Fibrosis 、 Liver disease 、 Extracellular matrix 、 Biomarker (medicine) 、 Internal medicine 、 Kinase 、 Biology 、 Endocrinology 、 Endoglin
摘要: Liver fibrosis is a common phenomenon that associated with several pathologies and characterized by excessive extracellular matrix deposition leads to progressive liver dysfunction. Bone morphogenetic protein 9 (BMP9) the most recently discovered member of BMP family. BMP9 bound high affinity activin receptor-like kinase 1 (ALK1) endoglin in non-parenchymal cells. In addition, activated Smad1/Smad5/Smad8 induced expression target genes inhibitor differentiation (Id1), hepcidin, Snail co-receptor Although role currently poorly understood, presence BMP9-activated proteins its have been reported be development. This review summarizes indirect connection between fibrosis, focus on signaling pathway members ALK1, endoglin, Id1, hepcidin Snail. The observations regulating may help understanding pathology mechanisms disease. Furthermore, could served as potent biomarker potential therapeutic drugs treat hepatocytes fibrosis.
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