Evidence from family studies for autoimmunity in dilated cardiomyopathy

摘要: Organ-specific antibodies are found in patients with autoimmune disease and their symptom-free relatives many years before clinical onset. cardiac can be dilated cardiomyopathy (DCM) relatives, which supports the idea that DCM is an disease. We did non-invasive cardiological assessment antibody screening 342 (170 male, 172 female, mean [SD] age 31 [16] years). 177 were from 33 families more than 1 affected individual (familial DCM) 165 only member (non-familial DCM). The frequency of was higher among controls (20% vs 3.5%, p = 0.0001). In 37 (58%) studied, proband and/or at least family common familial non-familial (24% 15%, 0.036). Antibody-positive younger (26 [15] [17] years, 0.01) had a larger echocardiographic left ventricular end-systolic dimension (35 [6] 32 [6], 0.01 mm) reduced percentage fractional shortening compared antibody-negative (31 34 0.008). Presence cardiac-specific autoantibodies provides evidence autoimmunity subset our (58%), including forms DCM. These associated mild systolic dysfunction on echocardiography may early markers for risk