Pre-existing Helicobacter pylori serum IgG enhances the vibriocidal antibody response to CVD 103-HgR live oral cholera vaccine in Malian adults.

摘要: Accumulating evidence indicates that persistent Helicobacter pylori gastric infection influences immune responses to oral enteric vaccines. We studied the association between pre-existing H. serum IgG and pepsinogens levels (PGs) as markers of inflammation response single-dose live cholera vaccine CVD 103-HgR in Malian adults. Baseline sera obtained during a phase 2 safety/immunogenicity clinical trial among 93 healthy adults were tested for antibodies PGI PGII using enzyme linked immunosorbent assays. Overall 74/93 (80%) recipients seropositive at baseline. Vibriocidal antibody seroconversion (≥ fourfold increase 14 days following administration compared baseline) was 56%. However, vibriocidal markedly higher seropositives than seronegatives 64% vs. 26% (p = 0.004); adjusted relative risk: 2.20 (95% confidence intervals 1.00-4.80; p 0.049). Among recipients, there no significant associations PGI, PGI:PGII seroconversion. The enhanced African provides further immunomodulating impact on immunogenicity.