Corticotropin-releasing factor as a transmitter in the human olivocerebellar pathway

摘要: This study demonstrates that the neuropeptide, corticotropin-releasing factor (CRF), is present in neurons of human inferior olivary complex (IOC). The medulla (including olive) and anterior vermis cerebellum 6 controls obtained at autopsy were immunostained with an antibody directed against CRF. CRF receptors localized labeled using vitro receptor autoradiography. great majority all divisions IOC expressed immunoreactivity, CRF-immunoreactive fibers demonstrated hilus olive molecular layer cerebellum, where they closely resembled climbing as visualized other methods. enriched highest density inner portions layer. These findings brain, consistent studies tissues from rat, cat, monkey, demonstrate may be a peptidergic transmitter fiber system are by cellular targets cerebellum.