Engineering human single-chain T cell receptors

Diana L. Thomas, Miri Kim, Natalie A. Bowerman, Samanthi Narayanan, David M. Kranz, Hans Schreiber, Edward J. Roy, Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells. Journal of Immunology. ,vol. 183, pp. 1828- 1837 ,(2009) , 10.4049/JIMMUNOL.0802322

D H Margulies, D Plaksin, K Polakova, P McPhie, A three-domain T cell receptor is biologically active and specifically stains cell surface MHC/peptide complexes. Journal of Immunology. ,vol. 158, pp. 2218- 2227 ,(1997)

Patrick Chames, Ralph A. Willemsen, Gertrudis Rojas, Detlef Dieckmann, Louise Rem, Gerold Schuler, Reinder L. Bolhuis, Hennie R. Hoogenboom, TCR-Like Human Antibodies Expressed on Human CTLs Mediate Antibody Affinity-Dependent Cytolytic Activity Journal of Immunology. ,vol. 169, pp. 1110- 1118 ,(2002) , 10.4049/JIMMUNOL.169.2.1110

Alan G. Baxter, Louis Pasteur's beer of revenge. Nature Reviews Immunology. ,vol. 1, pp. 229- 232 ,(2001) , 10.1038/35105083

Paul F. Robbins, Yong F. Li, Mona El-Gamil, Yangbing Zhao, Jennifer A. Wargo, Zhili Zheng, Hui Xu, Richard A. Morgan, Steven A. Feldman, Laura A. Johnson, Alan D. Bennett, Steven M. Dunn, Tara M. Mahon, Bent K. Jakobsen, Steven A. Rosenberg, Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions Journal of Immunology. ,vol. 180, pp. 6116- 6131 ,(2008) , 10.4049/JIMMUNOL.180.9.6116

K. C. Garcia, M. Degano, R. L. Stanfield, A. Brunmark, M. R. Jackson, P. A. Peterson, L. Teyton, I. A. Wilson, An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. ,vol. 274, pp. 209- 219 ,(1996) , 10.1126/SCIENCE.274.5285.209

Christian Blank, Ian Brown, Aalok K. Kacha, Mary A. Markiewicz, Thomas F. Gajewski, ICAM-1 contributes to but is not essential for tumor antigen cross-priming and CD8+ T cell-mediated tumor rejection in vivo Journal of Immunology. ,vol. 174, pp. 3416- 3420 ,(2005) , 10.4049/JIMMUNOL.174.6.3416

Andreas A. Hombach, Verena Schildgen, Claudia Heuser, Ricarda Finnern, David E. Gilham, Hinrich Abken, T Cell Activation by Antibody-Like Immunoreceptors: The Position of the Binding Epitope within the Target Molecule Determines the Efficiency of Activation of Redirected T Cells Journal of Immunology. ,vol. 178, pp. 4650- 4657 ,(2007) , 10.4049/JIMMUNOL.178.7.4650

Eric T. Boder, K. Dane Wittrup, Yeast surface display for directed evolution of protein expression, affinity, and stability. Methods in Enzymology. ,vol. 328, pp. 430- 444 ,(2000) , 10.1016/S0076-6879(00)28410-3

A Hiasa, H Nishikawa, M Hirayama, S Kitano, S Okamoto, H Chono, S S Yu, J Mineno, Y Tanaka, N Minato, I Kato, H Shiku, Rapid alphabeta TCR-mediated responses in gammadelta T cells transduced with cancer-specific TCR genes. Gene Therapy. ,vol. 16, pp. 620- 628 ,(2009) , 10.1038/GT.2009.6