Molecular Cloning and Physiological Analysis of the Start Gene cdc25 in Budding Yeast

摘要: There is increasing interest for the yeast Saccharomyces cevevisiae in studies on regulatory mechanisms of cell proliferation, since it particularly well characterized from biochemical and genetic point view furthermore recombinant DNA techniques have now greatly enhanced power classical genetics (Hinnen et al. 1978). S. cerevisiae presents a major cycle control function G1 , area called Start (Hartwell 1974, Hartwell 1974). At an integrates many intracellular environmental signals, then committed to continue proliferation or switched differentiative pathways such as sporulation, conjugation, entry stationary phase. Growth critical size appears be required among other conditions traverse replication division (Nurse 1981, Pringle 1981).